反应详情

温度

0 °C

Add benzyl chloroformate (0.712 g, 4.17 mmol), triethylamine (0.464 g, 4.59 mmol), and 4-dimethylaminopyridine (0.051 g, 0.42 mmol) to a solution of 6-methyl-4-oxo-heptanoic acid (0.66 g, 4.17 mmol) in dichloromethane (13 mL) at 0° C. Stir at 0° C. for 1 hour. Add saturated aqueous ammonium chloride (30 mL). Extract with dichloromethane (1×50 mL). Dry organic phase over magnesium sulfate and concentrate under reduced pressure. Subject residue to silica gel chromatography, eluting with 0-50% ethyl acetate in hexane to provide 0.87 g (84.1%) of the desired compound.

1. extractionExtract with dichloromethane (1×50 mL)
2. concentrationDry organic phase over magnesium sulfate and concentrate under reduced pressure
3. washSubject residue to silica gel chromatography, eluting with 0-50% ethyl acetate in hexane