Ethyl Acetate → HCID 67494680, compound

Temperature

-78 °C

Cyclohexane-1,4-dicarboxylic acid monomethyl ester (26.9 mmol, 5.0 g) and N,N′-carbonyldiimidazole (33.6 mmol, 5.44 g) in anhydrous THF (80 mL) were stirred 16 h at room temperature under argon. In a separate, sealed and argon-flushed flask, lithium HMDS (1.0 M in THF, 56.5 ml) is added to 40 mL anhydrous THF stirring at −78° C. To this solution is added dropwise anhydrous ethyl acetate (57.8 mmol, 5.65 mL). This solution is allowed to stir at −78° C. for 1 hour prior to dropwise addition of original CDI/acid solution that had been stirring overnight. The reaction mixture was allowed to stir and warm to room temperature overnight. The reaction is then quenched with saturated NH4Cl(aq) (200 mL) and extracted with Et2O (100×2). The combined organics are then washed with water, saturated brine, and dried over Na2SO4. The solvent was removed in vacuo and the crude residue (8.5 g) was used in the next step without further purification.

1. customIn a separate, sealed
2. customargon-flushed flask
3. additionlithium HMDS (1.0 M in THF, 56.5 ml) is added to 40 mL anhydrous THF stirring at −78° C
4. stirringhad been stirring overnight
5. stirringto stir
6. temperaturewarm to room temperature overnight
7. customThe reaction is then quenched with saturated NH4Cl(aq) (200 mL)
8. extractionextracted with Et2O (100×2)
9. washThe combined organics are then washed with water, saturated brine
10. dry with materialdried over Na2SO4
11. customThe solvent was removed in vacuo
12. customthe crude residue (8.5 g) was used in the next step without further purification

ORD record

ord-f3818668dbaa451ab645c895af5ab79b

Source dataset

uspto-grants-2013_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08591943B2