1,1'-Carbonyldiimidazole → HCID 66733615, compound

HRID 2047142Notes

Reaction equation

HRID 2047142 reaction equation
[CH2:1]([O:8][C@H:9]([CH3:14])[C:10]([NH:12][NH2:13])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1N=CN([C:20](N2C=NC=C2)=[O:21])C=1>C1COCC1>[CH2:1]([O:8][C@@H:9]([C:10]1[O:11][C:20](=[O:21])[NH:13][N:12]=1)[CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 66733484HCID 66733484, compound

Product 1

HCID 66733615HCID 66733615, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of (R)-2-(benzyloxy)propanehydrazide (194 mg, 1 mmol) in anhydrous THF (2 mL) was added CDI (178 mg, 1.1 mmol) and the resulting mixture was allowed to stir one hour. Solvent was removed under reduced pressure and the residue was purified on silica gel. Elution with EtOAc yielded title product.

Workup

  1. customSolvent was removed under reduced pressure
  2. customthe residue was purified on silica gel
  3. washElution with EtOAc

Sources & evidence

ORD record
ord-47cf6f7ebde240dc92b2aef5f4395461
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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