反应详情

温度

200 °C

A mixture of methoxyacetic acid (15 g), aminoguanidine sulfate (21 g) and 1,2,4-trichlorobenzene (20 mL) was stirred at 200° C. for 24 hr. The reaction mixture was poured into saturated aqueous sodium hydrogen carbonate, and the mixture was extracted with n-butanol. The obtained n-butanol layer was concentrated, and the residue was purified by silica gel column chromatography to give the title compound as a colorless solid (15 g, 75%).

1. extractionthe mixture was extracted with n-butanol
2. concentrationThe obtained n-butanol layer was concentrated
3. customthe residue was purified by silica gel column chromatography