Hydrochloric Acid → HCID 20344099, compound

HRID 2049627Notes

Reaction equation

HRID 2049627 reaction equation
I[C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[N+](C1C=CC=CC=1)([O-])=O.C(=O)([O-])[O-].[K+].[K+].[F:26][C:27]1[CH:28]=[C:29]([OH:33])[CH:30]=[CH:31][CH:32]=1.Cl>O.[Cu]>[F:26][C:27]1[CH:28]=[C:29]([CH:30]=[CH:31][CH:32]=1)[O:33][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 69412-Iodobenzoic acidHCID 7416NitrobenzeneHCID 97433-FluorophenolHCID 11430Potassium Carbonate2×

Product 1

HCID 20344099HCID 20344099, compound

Reagents, catalysts & solvents 2

HCID 23978CopperCatalystHCID 962WaterSolvent

Procedure

o-Iodobenzoic acid (12.4 g.) and nitrobenzene (5 ml.) were treated under stirring at 140°-150° with 3.4 g. of anhydrous potassium carbonate; the mixture was stirred for 10 minutes at 160°, and 3-fluorophenol (7 g.) was added, followed by portionwise addition of potassium carbonate (7 g.) and copper powder (0.1 g.) The mixture was stirred at 160°-165° for 45 minutes, cooled, diluted with water, and treated with 5 N HCl to give the title compound, m.p. 122°. ##STR9##

Workup

  1. stirringthe mixture was stirred for 10 minutes at 160°
  2. stirringwas stirred at 160°-165° for 45 minutes
  3. temperaturecooled

Sources & evidence

ORD record
ord-bee3207e16e24caaac3af1fb7ebee5e0
Source dataset
uspto-grants-1980_04
Patent number
US04198421

Reaction notes

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