Potassium Iodide → HCID 20344057, compound

HRID 2049681Notes

Reaction equation

HRID 2049681 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[S:6][C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[C:13]3([C:19](=[O:20])[C:4]=2[CH:3]=1)[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3.C(=O)(O)[O-].[Na+].[I-].[K+].[CH2:30](Br)[C:31]#[CH:32]>CN(C)C=O>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[S:6][C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[C:13]3([C:19](=[O:20])[C:4]=2[CH:3]=1)[CH2:14][CH2:15][N:16]([CH2:32][C:31]#[CH:30])[CH2:17][CH2:18]3

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 7842Propargyl bromideHCID 516892Sodium BicarbonateHCID 20344046HCID 20344046, compound

Product 1

HCID 20344057HCID 20344057, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2.5 g of 2-chloro-10,11-dihydro-11-oxospiro[dibenz(b,f)thiepin-10,4'-piperidine], free base of Example 5, 2.5 g of sodium bicarbonate, 2.0 g of potassium iodide and 1.1 g of propargyl bromide in 30 ml of dimethylformamide is treated according to the procedure of Example 16 to provide 2-chloro-10,11-dihydro-11-oxo-1'-(2-propynyl)spiro[dibenz(b,f)thiepin-10,4'-piperidine].

Workup

  1. additionis treated

Sources & evidence

ORD record
ord-1c2bd3dd15e543018864b4656f4e6dd6
Source dataset
uspto-grants-1980_04
Patent number
US04198420

Reaction notes

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