Tributylstannane → HCID 12878307, compound

HRID 2049709Notes

Reaction equation

HRID 2049709 reaction equation
[OH:1][C:2]1([CH3:24])[CH:8](Br)[CH:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:12][CH:11]=2)[O:6][C:4](=[O:5])[CH2:3]1.C([SnH](CCCC)CCCC)CCC>O1CCCC1>[OH:1][C:2]1([CH3:24])[CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:12][CH:11]=2)[O:6][C:4](=[O:5])[CH2:3]1

Participants

4

Reactant 2

HCID 5948TributylstannaneHCID 12878297HCID 12878297, compound

Product 1

HCID 12878307HCID 12878307, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product obtained by reducing 2.0 g of 3-hydroxy-3-methyl-4-bromo-5-(p-benzyloxyphenyl)-5-pentanolide with 5.99 g of tri-n-butyltin hydride in 40 ml of anhydrous tetrahydrofuran according to the method described in Example 2 (a), was separated by a thin layer chromatography into two isomers in a total yield of 1.40 g.

Workup

  1. customThe product obtained
  2. customwas separated by a thin layer chromatography into two isomers in a total yield of 1.40 g

Sources & evidence

ORD record
ord-3de33ce29f194536825d6c03de10a85e
Source dataset
uspto-grants-1980_04
Patent number
US04198425

Reaction notes

Loading…