反应详情

A mixture of 4chlorophenol (10 g, 0.78 mol) and sodium hydride (1.9 g, 0.08 mol) is heated to reflux for 30 min in 30 ml of THF and then cooled. 3-Chloro-2-methyl-1-propene (7.3 g, 0.08 mol) in 10 ml THF is added and the mixture is heated to reflux. After 24 hr, an additional equivalent of 3-chloro-2-methyl-1-propene is added and the mixture heated under reflux for another 24 hr. The reaction mixture is cooled and diluted with ether to 150 ml, washed with 20% NaOH (2X) and with water until neutral, then dried and solvent is removed to yield 3-(4-chloro-phenoxy)-2-methyl-1-propene.

1. temperatureis heated
2. temperaturecooled
3. temperaturethe mixture is heated to reflux
4. temperaturethe mixture heated
5. temperatureunder reflux for another 24 hr
6. temperatureThe reaction mixture is cooled
7. washwashed with 20% NaOH (2X) and with water until neutral,
8. customthen dried
9. customsolvent is removed