反应详情

When p-methoxybenzyl alcohol, isoborneol, benzyl alcohol or 2,2,2-trichloroethanol is substituted for t-butanol in Preparation 5 in the reaction with methyl cis-3-amino-1-(2,4-dimethoxybenzyl)-4-oxoazetidine-2-carboxylate, methyl cis-1-(2,4-dimethoxybenzyl)-3-(p-methoxybenzyloxycarbonylamino)-4-oxoazetidine-2-carboxylate, methyl cis-1-(2,4-dimethoxybenzyl)-3-isobornyloxycarbonylamino-4-oxoazetidine-2-carboxylate, methyl cis-3-benzyloxycarbonylamino-1-(2,4-dimethoxybenzyl)-4-oxoazetidine-2-carboxylate or methyl cis-1-(2,4-dimethoxybenzyl)-4-oxo-3-(2,2,2-trichloroethoxycarbonylamino)-azetidine-2-carboxylate is obtained, respectively.