反应详情

A mixture of 1-bromo-2,4,5-trifluorobenzene (5.0 g, 23.7 mmol), 4-pentyn-1-ol (2.4 ml, 26 mmol), palladium bis(triphenylphosphine chloride (5 mg), copper (I) iodide (5 mg) in triethylamine (30 ml) was refluxed under argon for 10 hours. On cooling, the mixture was acidified with dilute hydrochloric acid and was extracted with ethyl ether. Evaporation of the extracts gave an oil, which was purified by chromatography on a silica column using 60% ethyl ether/hexane to give the title alcohol.

1. temperaturewas refluxed under argon for 10 hours
2. temperatureOn cooling
3. extractionwas extracted with ethyl ether
4. customEvaporation of the extracts
5. customgave an oil, which
6. customwas purified by chromatography on a silica column