Triethylamine → HCID 178441985, compound

HRID 2050885Notes

Reaction equation

HRID 2050885 reaction equation
[C:1]([C:5]1[N:9]=[C:8]([S:10][CH2:11][CH2:12][OH:13])[NH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[F:21][C:22]([F:33])([F:32])[C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[O:31])=[CH:25][CH:24]=1>C(Cl)(Cl)Cl>[C:1]([C:5]1[N:9]=[C:8]([S:10][CH2:11][CH2:12][O:13][C:30](=[O:31])[NH:29][C:26]2[CH:27]=[CH:28][C:23]([C:22]([F:21])([F:33])[F:32])=[CH:24][CH:25]=2)[NH:7][N:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 737684-(Trifluoromethyl)phenyl isocyanateHCID 178441986HCID 178441986, compound

Product 1

HCID 178441985HCID 178441985, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To 5 g (20 mmole) of 3-t-butyl-5-(2-hydroxyethylthio)-1H-1,2,4-triazole in 50 ml of chloroform was added 0.1 g of triethylamine and 3.8 g (20 mmole) of 4-trifluoromethylphenylisocyanate. After refluxing for three hours, the mixture was concentrated in vacuo and crystallized from ether/hexane to give 3-t-butyl-5-(2-(4-trifluoromethylphenylcarbamoyloxy)-ethylthio)-1H-1,2,4-triazole.

Workup

  1. temperatureAfter refluxing for three hours
  2. concentrationthe mixture was concentrated in vacuo
  3. customcrystallized from ether/hexane

Sources & evidence

ORD record
ord-c57afbab7f12482d88aa2456ed68a5f2
Source dataset
uspto-grants-1991_05
Patent number
US05015652

Reaction notes

Loading…