Hydrochloric Acid → HCID 178459415, compound

HRID 2051705Notes

Reaction equation

HRID 2051705 reaction equation
[CH:1]([N:14]1[C:18]([C:19]([OH:21])=[O:20])=[CH:17][N:16]=[C:15]1[SH:22])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH2:24](O)[CH2:25][CH3:26]>>[CH:1]([N:14]1[C:18]([C:19]([O:21][CH2:24][CH2:25][CH3:26])=[O:20])=[CH:17][N:16]=[C:15]1[SH:22])([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 10311-PropanolHCID 178524782HCID 178524782, compound

Product 1

HCID 178459415HCID 178459415, compound

Procedure

3.1 g (0.01 mol) of 1-benzhydryl-2-mercapto-5-imidazole carboxylic acid (Example 2a) and 100 cc of 1-propanol were heated to 97° C. while introducing gaseous hydrogen chloride until esterification was completed. Working up in a basic medium yielded 3.3 g (94% of the theory) of 1-benzhydryl-2-mercapto-5-propoxycarbonyl-imidazole, m.p. 133° C.

Sources & evidence

ORD record
ord-84b4a71b2a1a4e91a58c5ec6634af89c
Source dataset
uspto-grants-1980_01
Patent number
US04182624

Reaction notes

Loading…