Amfenac → Ethyl (2-amino-3-benzoylphenyl)acetate

HRID 2051875Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2051875
[Na].[NH2:2][C:3]1[C:8]([C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:17][C:18]([OH:20])=[O:19].CN(C)C=O.[CH2:26](I)[CH3:27]>O>[NH2:2][C:3]1[C:8]([C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:17][C:18]([O:20][CH2:26][CH3:27])=[O:19]

Komponenten

6

Edukt 4

HCID 2136AmfenacHCID 6228DimethylformamideHCID 6340IodoethaneHCID 5360545Sodium

Produkt 1

HCID 12901249Ethyl (2-amino-3-benzoylphenyl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 2.5 g. (0.009 mole) of the sodium salt of 2-amino-3-benzoylphenylacetic acid in 25 ml. of dry dimethylformamide was treated with 5.0 g. (0.035 mole) of ethyl iodide. The mixture was stirred two hours at room temperature using a magnetic stirrer. The mixture was diluted with water and the aqueous solution extracted several times with ethyl ether. The combined extracts were washed with water, dried over sodium sulfate and concentrated under vacuum to a yellow solid. The solid was recrystallized from absolute ethanol to give 1.7 gms. (61.0%) of yellow needles which melted at 77°-78° C.

Aufarbeitung

  1. extractionthe aqueous solution extracted several times with ethyl ether
  2. washThe combined extracts were washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under vacuum to a yellow solid
  5. customThe solid was recrystallized from absolute ethanol
  6. customto give 1.7 gms

Quellen und Nachweise

ORD-Eintrag
ord-52094015735e44729a328b8f3f3c8fc3
Quelldatensatz
uspto-grants-1980_01
Patentnummer
US04182774

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