反应详情

A solution of 2.5 g. (0.009 mole) of the sodium salt of 2-amino-3-benzoylphenylacetic acid in 25 ml. of dry dimethylformamide was treated with 5.0 g. (0.035 mole) of ethyl iodide. The mixture was stirred two hours at room temperature using a magnetic stirrer. The mixture was diluted with water and the aqueous solution extracted several times with ethyl ether. The combined extracts were washed with water, dried over sodium sulfate and concentrated under vacuum to a yellow solid. The solid was recrystallized from absolute ethanol to give 1.7 gms. (61.0%) of yellow needles which melted at 77°-78° C.

1. extractionthe aqueous solution extracted several times with ethyl ether
2. washThe combined extracts were washed with water
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated under vacuum to a yellow solid
5. customThe solid was recrystallized from absolute ethanol
6. customto give 1.7 gms