反应详情

温度

25 °C

3.2 g (0.1315 mol) of sodium hydride were added in portions to a suspension of 30 g (0.1315 mol) of 3-phenylxanthine in 600 ml of DMF, the mixture was stirred at 25° C. for 30 minutes and then heated to 80° C. 27 g (0.1578 mol) of benzyl bromide were then added and the solution was left at 80° C. for 6 hours. After cooling to 50° C., the reaction mixture was poured into 2000 ml of ice-water, and the precipitate obtained was filtered off with suction, washed well with water and dried under reduced pressure. The dry residue was crystallized from dioxane/methanol.

1. temperatureheated to 80° C
2. waitthe solution was left at 80° C. for 6 hours
3. temperatureAfter cooling to 50° C.
4. customthe precipitate obtained
5. filtrationwas filtered off with suction
6. washwashed well with water
7. customdried under reduced pressure
8. customThe dry residue was crystallized from dioxane/methanol