Dimethylcarbamoyl Chloride → HCID 20377181, compound

HRID 2052204Notes

Reaction equation

HRID 2052204 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH3:8])=[C:5]([CH3:7])[N:6]=1.[CH3:9][N:10]([CH3:14])[C:11](Cl)=[O:12].[Cl-].[Al+3].[Cl-].[Cl-]>C1(C)C(C)=CC=CC=1>[CH3:9][N:10]([CH3:14])[C:11]([NH:1][C:2]1[S:3][C:4]([CH3:8])=[C:5]([CH3:7])[N:6]=1)=[O:12]

Participants

5

Reactant 3

HCID 6598Dimethylcarbamoyl ChlorideHCID 732382-Amino-4,5-dimethyl-1,3-thiazoleHCID 6451240Aluminum(III) Chloride

Product 1

HCID 20377181HCID 20377181, compoundYield 91.5%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

Using 2-amino-4,5-dimethylthiazole (1.28 g), N,N-dimethylcarbamoyl chloride (1.29 g), aluminum chloride (1.60 g), and xylene (40 ml), the reaction is run as in Example 1, whereby 1,1-dimethyl-3-(4,5-dimethyl-2-thiazolyl)urea (1.82 g) is obtained. Yield is 91.5%. Melting point is 202.5° to 204° C. (after recrystallization from ethyl acetate).

Sources & evidence

ORD record
ord-0c0d9af78a8e4309815ae68b6bb67f27
Source dataset
uspto-grants-1980_01
Patent number
US04183856

Reaction notes

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