Potassium Carbonate → N1-(1-benzoylethyl)-N4-phenacyl-piperazine dihydrochloride

HRID 2052810Notes

Reaction equation

HRID 2052810 reaction equation
Br[CH:2]([CH3:11])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[ClH:12].Cl.[CH2:14]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)[C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:16].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:12].[ClH:12].[C:3]([CH:2]([N:26]1[CH2:27][CH2:28][N:23]([CH2:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])[CH2:24][CH2:25]1)[CH3:11])(=[O:4])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 164522-BromopropiophenoneHCID 230805121-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2)

Product 1

HCID 69223708N1-(1-benzoylethyl)-N4-phenacyl-piperazine dihydrochloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-bromo-1-phenylpropan-1-one (3 mmol), N-phenacyl piperazine dihydrochloride (2.5 mmol) and K2CO3 (8.75 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-8), 0.64 g (62%), mp 236-238° C., M+ 336.

Workup

  1. additionwas treated
  2. customaccording to the general preparation 2
  3. customto give compound (IV-8), 0.64 g (62%), mp 236-238° C., M+ 336

Sources & evidence

ORD record
ord-117ee85942aa4b419b67cbdb492067df
Source dataset
uspto-grants-2008_02
Patent number
US07326710B2

Reaction notes

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