Potassium Carbonate → HCID 131726749, compound

HRID 2052816Notes

Reaction equation

HRID 2052816 reaction equation
[F:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH2:4][S:5]([Cl:8])(=[O:7])=[O:6].Cl.Cl.[CH2:16]([N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)[C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:18].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:8].[CH2:16]([N:25]1[CH2:30][CH2:29][N:28]([S:5]([CH2:4][C:3]2[CH:9]=[CH:10][C:11]([F:13])=[CH:12][C:2]=2[F:1])(=[O:7])=[O:6])[CH2:27][CH2:26]1)[C:17]([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:18]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 2761455(2,4-difluorophenyl)methanesulfonyl ChlorideHCID 230805121-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2)

Product 1

HCID 131726749HCID 131726749, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2,4-difluorobenzylsulfonylchloride (3.5 mmol), N-phenacyl piperazine dihydrochloride (3 mmol), and K2CO3 (10.5 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-22), 0.81 g (71%), M+ 412.

Workup

  1. additionwas treated
  2. customaccording to the general preparation 2
  3. customto give compound (IV-22), 0.81 g (71%), M+ 412

Sources & evidence

ORD record
ord-b7a1702e17a248c981400a4ce97ed0ca
Source dataset
uspto-grants-2008_02
Patent number
US07326710B2

Reaction notes

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