Potassium Carbonate → HCID 69224686, compound

HRID 2052817Notes

Reaction equation

HRID 2052817 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:4].[ClH:13].Cl.[CH3:15][O:16][C:17]1[CH:31]=[CH:30][C:20]([C:21](=[O:29])[CH2:22][N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:19][CH:18]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:1].[ClH:13].[CH3:15][O:16][C:17]1[CH:18]=[CH:19][C:20]([C:21](=[O:29])[CH2:22][N:23]2[CH2:28][CH2:27][N:26]([CH2:2][C:3]([NH:5][CH2:6][C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[O:4])[CH2:25][CH2:24]2)=[CH:30][CH:31]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 96233N-Benzyl-2-chloroacetamideHCID 52983664HCID 52983664, compound

Product 1

HCID 69224686HCID 69224686, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of chloroacetylbenzylamine (3.06 mmol), N-(4-methoxyphenacyl) piperazine dihydrochloride (3 mmol, prepared by using the general preparation 1) and K2CO3 (10.5 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-28), 0.86 g (74%), M+ 381.

Workup

  1. customprepared
  2. additionwas treated
  3. customaccording to the general preparation 2
  4. customto give compound (IV-28), 0.86 g (74%), M+ 381

Sources & evidence

ORD record
ord-6097bb3e4cb4461bb48b035b8396fba2
Source dataset
uspto-grants-2008_02
Patent number
US07326710B2

Reaction notes

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