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HRID2053925

反应详情

EQUATION

反应方程式

HRID 2053925 的结构方程式

REACTANTS

反应物

5
结构：ClCl
HCID24526

Chlorine

Cl2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：C[C@H](N)c1nc2ccc(Cl)cc2[nH]1
HCID42034613

未命名化合物

结构：O=C(O)c1ccc(S(=O)(=O)N2CCCC2)c(Cl)c1
HCID69311154

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H](NC(=O)c1ccc(S(=O)(=O)N2CCCC2)c(Cl)c1)c1nc2ccc(Cl)cc2[nH]1
HCID59655038

未命名化合物

收率 50%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Prepared analogously to Example 1g from 3-chloro-4-(pyrrolidin-1-ylsulfonyl)benzoic acid, TBTU, diisopropylethylamine, and (1S)-1-(6-chloro-1H-benzimidazol-2-yl)ethylamine in dimethylformamide. Yield: 50%; Rf value: 0.57 (silica gel; ethyl acetate); C20H20Cl2N4O3S (467.38); mass spectrum: (M+H)+=467/469/471 (chlorine isotope).