HRID2054342

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6212

Chloroform

CHCl3

结构：O=C1c2ccccc2C(=O)N1CC(OC1CCCCO1)c1cc2cccnc2[nH]1

HCID59655782

未命名化合物

PRODUCTS

生成物

HCID8080

3,4-Dihydro-2H-pyran

C5H8O

结构：O=C1c2ccccc2C(=O)N1CC(OC1CCCCO1)c1cc2c(Cl)ccnc2[nH]1

HCID59655772

未命名化合物

收率 63%

结构：O=C1c2ccccc2C(=O)N1CC(O)c1cc2c(Cl)ccnc2[nH]1

HCID59655775

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID241

Benzene

C6H6

溶剂HCID313

Hydrochloric Acid

ClH

PROCEDURE

实验过程

Following the same procedure as for 2-[2-Phthalimido-1-(2,3,5,6-tetrahydropyran-2-yl)oxyethyl]-7-azaindole, from 8c (1.3 g, 3.8 mmol) in CHCl3 (50 ml), 6N HCl in benzene (5 ml) and 2,3-dihydropyrane (1.7 ml, 19 mmol), 4-chloro-2-[2-phthalimido-1-(2,3,5,6-tetrahydropyran-2-yl)oxyethyl]-7-azaindole (1.0 g, 63%) as a diastereomeric mixture (1:1) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-912be7c518324f59bea3e4e995ef9408
来源数据集: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07329666B2
来源说明: uspto-grants-2008_02

反应 SMILES

[C:1]1(=[O:29])[N:5]([CH2:6][CH:7]([C:15]2[NH:16][C:17]3[C:22]([CH:23]=2)=[CH:21][CH:20]=[CH:19][N:18]=3)[O:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][O:10]2)[C:4](=[O:24])[C:3]2=[CH:25][CH:26]=[CH:27][CH:28]=[C:2]12.[CH:30]([Cl:33])(Cl)[Cl:31]>Cl.C1C=CC=CC=1>[Cl:31][C:21]1[CH:20]=[CH:19][N:18]=[C:17]2[C:22]=1[CH:23]=[C:15]([CH:7]([OH:8])[CH2:6][N:5]1[C:4](=[O:24])[C:3]3=[CH:25][CH:26]=[CH:27][CH:28]=[C:2]3[C:1]1=[O:29])[NH:16]2.[O:10]1[CH:9]=[CH:14][CH2:13][CH2:12][CH2:11]1.[Cl:33][C:30]1[CH:20]=[CH:19][N:18]=[C:17]2[C:22]=1[CH:23]=[C:15]([CH:7]([O:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][O:10]1)[CH2:6][N:5]1[C:4](=[O:24])[C:3]3=[CH:25][CH:26]=[CH:27][CH:28]=[C:2]3[C:1]1=[O:29])[NH:16]2