Sodium Bicarbonate → HCID 178427425, compound

HRID 2054362Notes

Reaction equation

HRID 2054362 reaction equation
C[O:2][C:3]1[C:8]2[C:9]([C:27]3[CH:32]=[CH:31][N:30]=[C:29]([NH:33]C(=O)C)[N:28]=3)=[C:10]3[CH:15]=[CH:14][N:13]=[C:12]([NH:16][S:17]([C:20]4[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=4)(=[O:19])=[O:18])[N:11]3[C:7]=2[N:6]=[CH:5][CH:4]=1.C([O-])(O)=O.[Na+]>Br>[OH:2][C:3]1[C:8]2[C:9]([C:27]3[CH:32]=[CH:31][N:30]=[C:29]([NH2:33])[N:28]=3)=[C:10]3[CH:15]=[CH:14][N:13]=[C:12]([NH:16][S:17]([C:20]4[CH:21]=[CH:22][C:23]([CH3:24])=[CH:25][CH:26]=4)(=[O:18])=[O:19])[N:11]3[C:7]=2[N:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 11364125HCID 11364125, compound

Product 1

HCID 178427425HCID 178427425, compoundYield 78.2%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A solution of 25 (10 mg, 0.02 mmol) in HBr (48%) was refluxed for 10 min. The solution was basified with NaHCO3 and extracted with CH2Cl2. The organic solution was dried, filtrated and evaporated to obtain 26 (7 mg, 78%) as a yellow solid.

Workup

  1. extractionextracted with CH2Cl2
  2. customThe organic solution was dried
  3. filtrationfiltrated
  4. customevaporated

Sources & evidence

ORD record
ord-ddc96d073e0047669cdb201fb1013a35
Source dataset
uspto-grants-2008_02
Patent number
US07329666B2

Reaction notes

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