Hydrochloric Acid → HCID 178520655, compound

HRID 2054554Notes

Reaction equation

HRID 2054554 reaction equation
[C:1]12([C:11]([NH:13][NH:14][C:15]([NH:17][CH2:18][CH2:19][CH2:20][CH2:21][OH:22])=[S:16])=O)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[OH-].[Na+].N#N.Cl>>[C:1]12([C:11]3[N:17]([CH2:18][CH2:19][CH2:20][CH2:21][OH:22])[C:15]([SH:16])=[N:14][N:13]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 947NitrogenHCID 14798Sodium HydroxideHCID 59656225HCID 59656225, compound

Product 1

HCID 178520655HCID 178520655, compound

Procedure

A mixture of 1-(1-adamantylcarbonyl)-4-(4-hydroxybutyl) thiosemicarbazide (H) (471 mg, 1.45 mmol) and 2 N NaOH (12 mL) was heated under reflux in a N2 atmosphere for 1.5 h. The cooled reaction was acidified with conc. HCl to pH 4. The precipitated solid was filtered, washed with water and dried to give 4-[3-(1-adamantyl)-5-mercapto-4H-1,2,4-triazol-4-yl] butan-1-ol (3-36).

Workup

  1. temperaturewas heated
  2. customThe cooled reaction
  3. filtrationThe precipitated solid was filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-664736aa4b38449eb7dbaaa2b987d612
Source dataset
uspto-grants-2008_02
Patent number
US07329683B2

Reaction notes

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