Potassium Carbonate → HCID 131726773, compound

HRID 2055229Notes

Reaction equation

HRID 2055229 reaction equation
[ClH:1].Cl.C1[C:17]2[CH:16]=[CH:15][CH:6]([C:7](=O)[N:8]3[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]3)[C:5](=O)[C:4]1=2.[Cl:19][CH:20]([CH3:36])[C:21]([C:23]1[CH:32]=[CH:31][C:30]2[C:25](=[CH:26][CH:27]=[C:28]([O:34][CH3:35])[C:29]=2[Cl:33])[CH:24]=1)=[O:22].[C:37]([O-])([O-:39])=[O:38].[K+].[K+]>CN(C=O)C>[ClH:19].[ClH:1].[CH2:37]1[O:39][C:17]2[CH:16]=[CH:15][C:6]([CH2:7][N:8]3[CH2:9][CH2:10][N:11]([CH:20]([C:21]([C:23]4[CH:32]=[CH:31][C:30]5[C:25](=[CH:26][CH:27]=[C:28]([O:34][CH3:35])[C:29]=5[Cl:33])[CH:24]=4)=[O:22])[CH3:36])[CH2:12][CH2:13]3)=[CH:5][C:4]=2[O:38]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 13699427HCID 13699427, compoundHCID 131726774HCID 131726774, compound

Product 1

HCID 131726773HCID 131726773, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of N-(3,4-methylenedioxobenzyl)piperazine dihydrochloride (1 g, 4.5 mmol), 2-chloro-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one (1.54 g, 5.4 mmol) and K2CO3 (1.57 g, 11.25 mmol) in 20 ml of DMF, was treated according to general preparation 2 to give 0.62 g of compound (IV-30), yield 70%, mp 230-232° C. M+ 466.

Workup

  1. additionwas treated
  2. customaccording to general preparation 2

Sources & evidence

ORD record
ord-c7797eac6ade444586608ce1877a571b
Source dataset
uspto-grants-2008_02
Patent number
US07332495B2

Reaction notes

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