Bis(2-pyridylmethyl)amine → HCID 11515602, compound

HRID 2056240Notes

Reaction equation

HRID 2056240 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][NH:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1.Cl[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][Cl:25])[N:19]=1>C1COCC1>[Cl:25][CH2:24][C:20]1[N:19]=[C:18]([CH2:17][N:8]([CH2:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 73759Bis(2-pyridylmethyl)amineHCID 3166542,6-Bis(chloromethyl)pyridine

Product 1

HCID 11515602HCID 11515602, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a 250 ml three-necked flask 1 equivalent of bis(2-pyridylmethyl)amine was dissolved in 100 ml of THF and the solution was admixed with 1 equivalent of 2,6-bis(chloromethyl)pyridine and 4 equivalents of N,N-diisopropylethylamide. The solution was stirred at room temperature for 7 days. The solution was filtered and the filtrate was purified by column chromatography.

Workup

  1. filtrationThe solution was filtered
  2. customthe filtrate was purified by column chromatography

Sources & evidence

ORD record
ord-e65a30acbbf04eb18041079875769fe3
Source dataset
uspto-grants-2008_02
Patent number
US07335629B2

Reaction notes

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