Water → (1-Methoxyethyl)(trimethyl)silane

HRID 205701Notes

Reaction equation

HRID 205701 reaction equation
[CH3:1][O:2][CH:3]([CH3:4])[Si:5]([CH3:6])([CH3:7])[CH3:8].[CH3:49][N:50]([CH3:51])[CH:52]=[O:53].[Cl:43][CH2:44][CH2:45][CH2:46][Br:47].[Cl:9][c:10]1[cH:11][cH:12][c:13]2[c:17]([cH:18]1)[NH:16][C:15](=[O:19])[C:14]21[CH:20]([c:34]2[cH:35][c:36]([Cl:40])[cH:37][cH:38][cH:39]2)[NH:21][C:22](=[O:33])[CH2:23][CH:24]1[c:25]1[c:26]([CH3:32])[cH:27][cH:28][c:29]([F:31])[cH:30]1.[H-:41].[Li+:42].[OH2:48]>>[CH3:1][O:2][CH:3]([CH3:4])[Si:5]([CH3:6])([CH3:7])[CH3:8].[Cl:9][c:10]1[cH:11][cH:12][c:13]2[c:17]([cH:18]1)[NH:16][C:15](=[O:19])[C:14]21[CH:20]([c:34]2[cH:35][c:36]([Cl:40])[cH:37][cH:38][cH:39]2)[N:21]([CH2:46][CH2:45][CH2:44][Cl:43])[C:22](=[O:33])[CH2:23][CH:24]1[c:25]1[c:26]([CH3:32])[cH:27][cH:28][c:29]([F:31])[cH:30]1

Participants

9

Reactant 7

HCID 962WaterHCID 6228DimethylformamideHCID 80061-Bromo-3-chloropropaneHCID 28486Lithium ionHCID 166653HydrideHCID 22400412(1-Methoxyethyl)(trimethyl)silaneHCID 76568090racemic (2'S,3S,4'R)-6-chloro-2'-(3-chlorophenyl)-4'-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Product 2

HCID 22400412(1-Methoxyethyl)(trimethyl)silaneHCID 775812716-chloro-6'-(3-chlorophenyl)-1'-(3-chloropropyl)-4'-(5-fluoro-2-methylphenyl)spiro[1H-indole-3,5'-piperidine]-2,2'-dione

Sources & evidence

ORD record
ord-68297ab0f4b443d69e4f41127d30486c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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