Sodium Carbonate → HCID 23249780, compound

HRID 2057114Notes

Reaction equation

HRID 2057114 reaction equation
N[C@@H:2]([CH:6](C)C)[C@H:3](O)[CH3:4].[NH2:9][C@@H:10]([CH:19]([CH3:21])[CH3:20])[C@@H:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[OH:12].C([O-])([O-])=O.[Na+].[Na+].C([O-])([O-])=O.[K+].[K+]>CCOC(C)=O.CCCCCC>[CH3:20][CH:19]([CH3:21])[C@H:10]([N:9]1[CH2:4][CH2:3][CH2:2][CH2:6]1)[C@@H:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[OH:12]

Participants

7

Reactant 4

HCID 10340Sodium CarbonateHCID 11430Potassium CarbonateHCID 10856884HCID 10856884, compoundHCID 13949662HCID 13949662, compound

Product 1

HCID 23249780HCID 23249780, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 8058HexaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

Repeat Step (a) of EXAMPLE 1, but replace (2R,3S)-3-amino-4-methylpentan-2-ol with (1R,2S)-2-amino-3-methyl-1-phenylbutan-1-ol, and replace Na2CO3 (1.16 g, 11.0 mmol) with K2CO3 (1.52 g, 11.0 mmol). Column chromatography (Silica gel, eluent is n-Hexane:EtOAc=10:1) is used to purify the coarse product and a slightly-yellow liquid (1.00 g) is obtained. The yield is 86% and the other analysis includes:

Workup

  1. customto purify the coarse product

Sources & evidence

ORD record
ord-1a29a8cf9fda42be91ac8898b736b392
Source dataset
uspto-grants-2008_02
Patent number
US07335781B2

Reaction notes

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