Trifluoroacetic acid → 67177-54-2

HRID 2057360Notes

Reaction equation

HRID 2057360 reaction equation
[CH2:1]1[C:7]2=[CH:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[N:6]2[CH2:5][CH2:4][CH2:3][NH:2]1.B.C1COCC1.FC(F)(F)C(O)=O>O1CCCC1>[CH2:1]1[CH:7]2[CH2:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[N:6]2[CH2:5][CH2:4][CH2:3][NH:2]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 33471AzepindoleHCID 2723981Borane;tetrahydrofuran

Product 1

HCID 1242466067177-54-2Yield 75%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In an operation carried out in a manner similar to that described in Example I but employing 22 grams of 2,3,4,5-tetrahydro-1H-[1,4]-diazepino[1,2-a]indole, milliliters of 1 M BH3.THF in tetrahydrofuran and milliliters of trifluoroacetic acid, a 75 percent yield of 2,3,4,5,11,11a-hexahydro-1H-[1,4]-diazepino[1,2-a]indole was obtained as determined by GLC on the isolated product.

Sources & evidence

ORD record
ord-c7147503121f4138945336cc6beb9ab5
Source dataset
uspto-grants-1980_07
Patent number
US04210590

Reaction notes

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