Potassium Carbonate → 2-Nitrosooctahydro-2H-pyrido[1,2-a]pyrazine

HRID 2057892Notes

Reaction equation

HRID 2057892 reaction equation
[CH2:1]1[NH:6][CH2:5][CH2:4][N:3]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:2]12.[N+:11]([O-])([O-])=[O:12].[Na+].C(=O)([O-])[O-].[K+].[K+]>Cl.O>[N:11]([N:6]1[CH2:5][CH2:4][N:3]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:2]2[CH2:1]1)=[O:12]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 24268Sodium NitrateHCID 2876391(+-)-1,4-Diazabicyclo[4.4.0]decane

Product 1

HCID 450994932-Nitrosooctahydro-2H-pyrido[1,2-a]pyrazine

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

Octahydropyrido-[1,2-a]-pyrazine (5 g) was dissolved in hydrochloric acid (5 N, 16 ml) and sodium nitrate (2.7 g) in water (10 ml) added dropwise at 0°. The solution was then heated at 60° for 30 minutes and stood at room temperature for 3 hours. It was basified, saturated with potassium carbonate and extracted with ether. The ethereal extract was dried and evaporated to give N-nitroso-octahydropyrido-[1,2-a]-pyrazine as an oil.

Workup

  1. temperatureThe solution was then heated at 60° for 30 minutes
  2. extractionextracted with ether
  3. extractionThe ethereal extract
  4. customwas dried
  5. customevaporated

Sources & evidence

ORD record
ord-efceddec38164246b24abb76587a7529
Source dataset
uspto-grants-1980_07
Patent number
US04213983

Reaction notes

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