5,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one → 11-(4-chlorobutyryl)-5,11-dihydro-6H-pyrido [2,3-b][1,4]-benzodiazepin-6-one

HRID 2057903Notes

Reaction equation

HRID 2057903 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][C:5](Cl)=[O:6].[N:8]1[C:13]2[NH:14][C:15]3[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=3[C:17](=[O:19])[NH:18][C:12]=2[CH:11]=[CH:10][CH:9]=1>C1(C)C(C)=CC=CC=1>[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([N:14]1[C:15]2[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=2[C:17](=[O:19])[NH:18][C:12]2[CH:11]=[CH:10][CH:9]=[N:8][C:13]1=2)=[O:6]

Participants

4

Reactant 2

HCID 701695,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 783704-Chlorobutyryl chloride

Product 1

HCID 1592561711-(4-chlorobutyryl)-5,11-dihydro-6H-pyrido [2,3-b][1,4]-benzodiazepin-6-one

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 4-chlorobutyryl chloride and 5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one in xylene was reacted to obtain 11-(4-chlorobutyryl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one which after crystallization from ethyl acetate melted at 205°-207° C.

Sources & evidence

ORD record
ord-cc6d7efbf6754777a00bf08387fb5a8e
Source dataset
uspto-grants-1980_07
Patent number
US04213985

Reaction notes

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