4-Methoxybenzaldehyde → HCID 178477497, compound

HRID 2059362Notes

Reaction equation

HRID 2059362 reaction equation
COc1ccc(C=O)cc1.CCSC(=O)C(OCc1ccccc1)C(=O)O>NCc1ccccc1.O=C(O)C(F)(F)F.CN(C)c1ccncc1.CN(C)C=O>CCSC(=O)/C(=C/c1ccc(OC)cc1)OCc1ccccc1

Participants

6

Reactant 2

HCID 312444-MethoxybenzaldehydeHCID 178477513HCID 178477513, compound

Product 1

HCID 178477497HCID 178477497, compoundYield 67%

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineReagentHCID 12484433Benzenemethanamine, trifluoroacetateCatalystHCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Workup

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Keep Organic
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Sources & evidence

ORD record
ord-54f6ab4595ee4cf3a40cbfdf84a28cbc
Source dataset
Transfer learning optimization of 26 decarboxylative olefination reactions

Reaction notes

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