Cyclopropanecarboxaldehyde → HCID 178477498, compound

HRID 2059395Notes

Reaction equation

HRID 2059395 reaction equation
O=CC1CC1.CCSC(=O)C(C)C(=O)O>C1CCNC1.CN(C)c1ccncc1.C1CCOC1>CCSC(=O)/C(C)=C/C1CC1

Participants

6

Reactant 2

HCID 123114CyclopropanecarboxaldehydeHCID 15250913HCID 15250913, compound

Product 1

HCID 178477498HCID 178477498, compoundYield 57%

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineReagentHCID 31268PyrrolidineCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
25 °C

Workup

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Keep Organic
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Sources & evidence

ORD record
ord-464cd081979c474aa076e42bd4b0e04b
Source dataset
Transfer learning optimization of 26 decarboxylative olefination reactions

Reaction notes

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