4-Nitrobenzaldehyde → HCID 178477505, compound

HRID 2059411Notes

Reaction equation

HRID 2059411 reaction equation
O=Cc1ccc([N+](=O)[O-])cc1.CCSC(=O)C(Cl)C(=O)O>NCc1ccccc1.O=C(O)C(F)(F)F.CN(C)c1ccncc1.C1CCOC1>CCSC(=O)/C(Cl)=C/c1ccc([N+](=O)[O-])cc1

Participants

6

Reactant 2

HCID 5414-NitrobenzaldehydeHCID 178477506HCID 178477506, compound

Product 1

HCID 178477505HCID 178477505, compoundYield 60%

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineReagentHCID 12484433Benzenemethanamine, trifluoroacetateCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
25 °C

Workup

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Keep Organic
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Sources & evidence

ORD record
ord-cfb86439157345e299f5fb4bb0d23269
Source dataset
Transfer learning optimization of 26 decarboxylative olefination reactions

Reaction notes

Loading…