4-Methoxybenzaldehyde → z-Methyl-2-chloro-3-(4'-methoxyphenyl)propenoate

HRID 2059426노트

반응식

HRID 2059426 반응식
COc1ccc(C=O)cc1.COC(=O)C(Cl)C(=O)O>C1CCNCC1.CN(C)c1ccncc1.Cc1ccccc1>COC(=O)/C(Cl)=C/c1ccc(OC)cc1

참가 물질

6

반응물 2

HCID 312444-MethoxybenzaldehydeHCID 179099592-Chloro-3-methoxy-3-oxopropanoic acid

생성물 1

HCID 12339865z-Methyl-2-chloro-3-(4'-methoxyphenyl)propenoate수율 0%

시약·촉매·용매 3

HCID 142844-(Dimethylamino)pyridine시약HCID 8082Piperidine촉매HCID 1140Toluene용매

반응 조건

온도
25 °C

후처리

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Organic 상 유지
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

출처 및 근거

ORD 기록
ord-3798ca403e3041ad8ce769f3333de485
출처 데이터셋
Transfer learning optimization of 26 decarboxylative olefination reactions

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