Cyclohexanecarboxaldehyde → HCID 178520439, compound

HRID 2059429Notes

Reaction equation

HRID 2059429 reaction equation
O=CC1CCCCC1.O=C(O)CC(=O)N(Cc1ccccc1)Cc1ccccc1>C1CCNC1.CN(C)c1ccncc1.C1CCOC1>O=C(/C=C/C1CCCCC1)N(Cc1ccccc1)Cc1ccccc1

Participants

6

Reactant 2

HCID 16275CyclohexanecarboxaldehydeHCID 62231246HCID 62231246, compound

Product 1

HCID 178520439HCID 178520439, compoundYield 31%

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineReagentHCID 31268PyrrolidineCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
25 °C

Workup

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Keep Organic
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Sources & evidence

ORD record
ord-535d787fea5e4e388b7a5d6851a72bc2
Source dataset
Transfer learning optimization of 26 decarboxylative olefination reactions

Reaction notes

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