Dimethylformamide dimethyl acetal → HCID 69079036, compound

HRID 2059730Notes

Reaction equation

HRID 2059730 reaction equation
[Br:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][NH:7][C:8](=[O:14])[CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.CO[CH:19](OC)[N:20]([CH3:22])[CH3:21]>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C:8]([C:9](=[CH:19][N:20]([CH3:22])[CH3:21])[C:10]([O:12][CH3:13])=[O:11])=[O:14])=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 69082365HCID 69082365, compound

Product 1

HCID 69079036HCID 69079036, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product of Step A (5.01 g, 17.5 mmol) in THF (30 mL) was treated to dimethylformamide dimethylacetal (4.97 mL, 35.0 mmol, 94% assay) at 60° C. for about an hour. The reaction was concentrated and used directly in Step C.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-b0097ade3fdc4160a8c312cd7c524e4e
Source dataset
uspto-grants-2012_10
Patent number
US08278304B2

Reaction notes

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