Tetrahydrofuran → Ethyl β-oxo-1H-imidazole-1-hexanoate

HRID 206009Notes

Reaction equation

HRID 206009 reaction equation
[C:12]([n:13]1[cH:14][cH:15][n:16][cH:17]1)([n:18]1[cH:19][cH:20][n:21][cH:22]1)=[O:23].[CH2:25]([CH3:26])[O:27][C:28]([CH2:29][C:30]([OH:31])=[O:32])=[O:33].[Mg:24].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1.[n:1]1([CH2:6][CH2:7][CH2:8][C:9](=[O:10])[OH:11])[cH:2][n:3][cH:4][cH:5]1>>[n:1]1([CH2:6][CH2:7][CH2:8][C:9](=[O:11])[CH2:29][C:28]([O:27][CH2:25][CH3:26])=[O:33])[cH:2][n:3][cH:4][cH:5]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 682631,1'-CarbonyldiimidazoleHCID 70615Monoethyl malonateHCID 3055390Imidazole-1-butyric acidHCID 5462224Magnesium

Product 1

HCID 22097627Ethyl β-oxo-1H-imidazole-1-hexanoate

Sources & evidence

ORD record
ord-a0e25c8d484344888564471d35dc16c5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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