反应详情

A mixture of 5 g of 4-(2-fluorobenzyloxy)benzaldehyde, prepared according to the Ex. 1 and the corresponding amount L-alaninamide hydrochloride and triethylamine is hydrogenated according to the same procedure of Example 2, but using wet (50% H2O) Pd/C 10% instead of wet (50% H2O) Pt/C 5% to obtain (S)-2-[4-(2-fluorobenzyloxy) benzylamino]propanamide (Ib) in a 70% yield.

1. customprepared