反应详情

{2-[2-(1-Ethoxy-vinyl)-benzyl]-thiazolo[5,4-d]pyrimidin-7-yl}-(4-trifluoromethyl-phenyl)-amine (230 mg, 0.62 mmol) was dissolved in THF (5 mL) and 2 N HCl (2 mL) and the reaction mixture was stirred at rt for 1.5 h. The reaction mixture was diluted with EtOAc (20 mL), washed with satd. aq. NaCl (2×5 mL), dried (Na2SO4), and concentrated to provide a white solid (0.23 g, 69%). MS (ESI): mass calcd. for C21H15F3N4OS, 428.4; m/z found, 429.1 [M+H]+. 1H NMR (CDCl3): 8.61 (s, 1H), 8.08 (s, 1H), 7.98 (d, J=8.5 Hz, 2H), 7.91 (dd, J=8.0, 1.2 Hz, 1H), 7.64 (d, J=8.6 Hz, 2H), 7.58-7.54 (m, 1H), 7.50-7.46 (m, 2H), 4.75 (s, 2H), 2.64 (s, 3H).

1. washwashed with satd
2. dry with materialaq. NaCl (2×5 mL), dried (Na2SO4)
3. concentrationconcentrated