Methylhydrazine → HCID 57938799, compound

HRID 2063597Notes

Reaction equation

HRID 2063597 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[N:3]=1.[CH3:13][NH:14][NH2:15].C(=O)([O-])[O-].[K+].[K+]>C1COCC1>[CH3:13][N:14]([C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[N:3]=1)[NH2:15]

Participants

5

Reactant 3

HCID 6061MethylhydrazineHCID 11430Potassium CarbonateHCID 27854214-Chloro-2-methylquinazoline

Product 1

HCID 57938799HCID 57938799, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared from 4-chloro-2-methylquinazoline (1.0 g, 5.6 mmol), N-methylhydrazine (0.89 mL, 16.8 mmol) and potassium carbonate (1.3 g, 22.4 mmol) in dry THF (20 mL) by a procedure similar to example 1, step 3 yielding 380 mg (36%) of a beige solid.

Sources & evidence

ORD record
ord-c280d2f41724486699ac728c0b8f3dce
Source dataset
uspto-grants-2012_10
Patent number
US08288398B2

Reaction notes

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