Chloride → 5-Bromo-2-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-isoindol-1-one
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH2:16][OH:17])[c:5]([C:6](=[O:7])[NH:8][CH2:9][C:10]([F:11])([F:12])[F:13])[cH:14][cH:15]1.[CH3:23][N:24]([CH3:25])[P:26]([Cl:27])([N:28]([CH3:29])[CH3:30])=[O:31].[CH3:37][N:38]1[CH2:39][C:40](=[O:41])[CH:42]=[CH:43]1.[CH:19]([Mg+:20])([CH3:21])[CH3:22].[Cl-:18].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([cH:14][cH:15]1)[C:6](=[O:7])[N:8]([CH2:9][C:10]([F:11])([F:12])[F:13])[CH2:16]2Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-7eabf26f80474f2f815155208c442e0a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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