反应详情

温度

32.5 °C

6-Chloro-3-nitro-pyridin-2-ylamine (16.2 kg, 93.3 mol), acetonitrile (130.8 L), cuprous iodide (0.18 kg, 1.0 mol), and bis(triphenylphosphine)palladium (II) chloride (0.66 kg, 0.9 mol) are combined under a nitrogen atmosphere at 20-25° C. with stirring. Triethylamine (19.7 L, 141.3 mol) is added and the mixture is heated to 30-35° C. A solution of 1-ethynyl-2,4-difluoro-benzene (18.0 kg, 130.3 mol) in acetonitrile (32.6 L) is added under a nitrogen atmosphere at 30-35° C. The mixture is stirred at 15-25° C. for 2-4 h. Toluene (80.0 L) is added and the mixture is stirred for 0.5-1 h, then cooled to 0-5° C. and stirred for 2-4 h. The reaction mixture is centrifuged and the filter cake is rinsed with toluene (2×64 L) and water (2×32.4 L). The solids are dried under reduced pressure below 50° C. to furnish the title compound as a yellow solid (21.7 kg, 83%).

1. customare combined under a nitrogen atmosphere at 20-25° C.
2. stirringThe mixture is stirred at 15-25° C. for 2-4 h
3. stirringthe mixture is stirred for 0.5-1 h
4. temperaturecooled to 0-5° C.
5. stirringstirred for 2-4 h
6. washthe filter cake is rinsed with toluene (2×64 L) and water (2×32.4 L)
7. customThe solids are dried under reduced pressure below 50° C.