反应详情

To a solution of 6-bromomethyl-2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (175 mg, 0.50 mmol) in DMF (5 mL) were added hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester (160 mg, 0.754 mmol) and potassium carbonate (136 mg, 0.984 mmol). The resulting mixture was stirred at RT for 2 h, then diluted with water and EtOAc. The organic layer was isolated, then washed with brine, dried (MgSO4) and concentrated in vacuo. The resulting residue was purified by column chromatography to give the title compound as an off-white solid (218 mg, 90%).

1. customThe organic layer was isolated
2. washwashed with brine
3. dry with materialdried (MgSO4)
4. concentrationconcentrated in vacuo
5. customThe resulting residue was purified by column chromatography