4-Methylmorpholine → 11-(3-Chloro-4-fluorobenzyl)-9-hydroxy-2-methyl-3,4,5,6,12,13-hexahydro-2H [1,4]diazocino[2,1-a]-2,6-naphthyridine-1,8,10(11H)-trione

HRID 2066577Notes

Reaction equation

HRID 2066577 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[F:31])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:26])[C:10](=[O:25])[N:11]([CH2:19][CH2:20][CH2:21][CH2:22][NH:23][CH3:24])[C:12]=2[C:16](O)=[O:17])[C:7]1=[O:27].Cl.CN(C)CCCN=C=NCC.ON1C2N=CC=CC=2N=N1.CN1CCOCC1>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[F:31])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:26])[C:10](=[O:25])[N:11]3[CH2:19][CH2:20][CH2:21][CH2:22][N:23]([CH3:24])[C:16](=[O:17])[C:12]3=2)[C:7]1=[O:27]

Participants

6

Reactant 4

HCID 79724-MethylmorpholineHCID 181649HOAtHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 669968806-(3-Chloro-4-fluorobenzyl)-4-hydroxy-2-[4-(methylamino)butyl]-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylic acid

Product 1

HCID 5469778811-(3-Chloro-4-fluorobenzyl)-9-hydroxy-2-methyl-3,4,5,6,12,13-hexahydro-2H [1,4]diazocino[2,1-a]-2,6-naphthyridine-1,8,10(11H)-trione

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-2-[4-(methylamino)butyl]-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylic acid (0.18 g, 0.40 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrocloride (0.08 g, 0.41 mmol), and 1-hydroxy-7-azabenzotriazole (0.07 g, 0.51 mmol), and N-methylmorpholine (0.35 mL, 3.16 mmol) in anhydrous DMF (3 mL) was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum. The residue was purified by reverse phase high pressure liquid chromatography. Collection and concentration of appropriate fractions provided the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. customThe residue was purified by reverse phase high pressure liquid chromatography
  3. customCollection and concentration of appropriate fractions

Sources & evidence

ORD record
ord-bc7831dfcd864e88815dd853a6fec922
Source dataset
uspto-grants-2012_10
Patent number
US08293731B2

Reaction notes

Loading…