Triphenylphosphine → HCID 58092761, compound

HRID 2066800Notes

Reaction equation

HRID 2066800 reaction equation
[N:1]([CH2:4][C@@H:5]1[CH2:9][CH2:8][N:7]([C@H:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH3:11])[C@@H:6]1[C:18]([NH2:20])=[O:19])=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[NH2:1][CH2:4][C@@H:5]1[CH2:9][CH2:8][N:7]([C@H:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH3:11])[C@@H:6]1[C:18]([NH2:20])=[O:19]

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 58092758HCID 58092758, compound

Product 1

HCID 58092761HCID 58092761, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of (2S,3S)-3-azidomethyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide (Step 5.3) (0.723 mmol) and triphenylphosphine (0.867 mmol) in THF (3 mL) was stirred at it for 25 h. The reaction mixture was concentrated to afford the crude title compound as a light brown solid. HPLC: tR 3.53 min (method B); ESI-MS: [M+H]+ 248.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-b952724aef5242508cca59f4ddcad9a5
Source dataset
uspto-grants-2012_10
Patent number
US08293753B2

Reaction notes

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