反应详情

(4-Fluoro-3-nitrophenyl)methanol (1.500 g, 0.008765 mol), N,N-diisopropylethylamine (3.054 mL, 0.01753 mol), N,N-dimethylformamide (3.688 mL, 0.04764 mol), and aniline (2.40 mL, 0.0263 mol) were placed into three separate microwave vials. Each was reacted at 150° C. for 30 minutes. The resultant gel was dissolved in ethyl acetate, washed once with 5% citric acid and once with brine, dried and concentrated. The residue was used directly in the next step.

1. customseparate microwave vials
2. customEach was reacted at 150° C. for 30 minutes
3. washwashed once with 5% citric acid and once with brine
4. customdried
5. concentrationconcentrated