Tetrahydrofuran → 4-{5-[8-(1-Ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazin-3-yl]-4-methyl-thiophen-2-yl}-tetrahydro-pyran-4-ol

HRID 206902Notes

Reaction equation

HRID 206902 reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH3:23])[c:5](-[c:7]2[c:8]([CH3:22])[n:9][c:10]3[n:11]2[n:12][c:13]([CH3:21])[cH:14][c:15]3[CH:16]([CH2:17][CH3:18])[CH2:19][CH3:20])[s:6]1.[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[CH3:36][CH2:37][O:38][C:39]([CH3:40])=[O:41].[O:29]1[CH2:30][CH2:31][C:32](=[O:35])[CH2:33][CH2:34]1>>[c:2]1([C:32]2([OH:35])[CH2:31][CH2:30][O:29][CH2:34][CH2:33]2)[cH:3][c:4]([CH3:23])[c:5](-[c:7]2[c:8]([CH3:22])[n:9][c:10]3[n:11]2[n:12][c:13]([CH3:21])[cH:14][c:15]3[CH:16]([CH2:17][CH3:18])[CH2:19][CH3:20])[s:6]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 121599Tetrahydro-4H-pyran-4-oneHCID 579329433-(5-Bromo-3-methyl-thiophen-2-yl)-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine

Product 1

HCID 579330514-{5-[8-(1-Ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazin-3-yl]-4-methyl-thiophen-2-yl}-tetrahydro-pyran-4-ol

Sources & evidence

ORD record
ord-4c8f045bda314377b04564fbefb1cc22
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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