反应详情

tert-Butyl (2R)-1-(8-amino-2-oxo-1,2,3,4-tetrahydroquinolin-3-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate (300 mg) was dissolved in ethyl acetate (5 mL), and 4-chlorobutyryl chloride (0.1 mL) and saturated aqueous sodium bicarbonate solution (5 mL) were added thereto. The mixture was stirred under cooling on ice for 45 minutes and then subjected to extraction with water and ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution, and was dried over sodium sulfate. The solvent was evaporated under reduced pressure, whereby the title compound (377 mg) was yielded.

1. temperatureunder cooling on ice for 45 minutes
2. extractionsubjected to extraction with water and ethyl acetate
3. washThe organic layer was washed with saturated aqueous sodium chloride solution
4. dry with materialwas dried over sodium sulfate
5. customThe solvent was evaporated under reduced pressure, whereby the title compound (377 mg)
6. customwas yielded