HRID2070753

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID168937

Lithium hydroxide hydrate

H3LiO2

结构：COC(=O)c1ccc(C)c(-n2ccnc(NC(C)(C)c3ccccc3OCCN(C)C(=O)OCc3ccccc3)c2=O)c1

HCID66690144

未命名化合物

PRODUCTS

生成物

HCID21882825

未命名化合物

结构：Cc1ccc(C(=O)O)cc1-n1ccnc(NC(C)(C)c2ccccc2OCCN(C)C(=O)OCc2ccccc2)c1=O

HCID66689694

未命名化合物

收率 186.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

2 次

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

To 4-Methyl-3-[3-[[1-methyl-1-[2-[2-[methyl[(phenylmethoxy)carbonyl]amino]ethoxy]phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-benzoic acid methyl ester (Example 220c, 1.97 g) in THF (11 mL) was added lithium hydroxide monohydrate (0.424 g) in water (5.5 mL) (sonicated suspension) and the reaction stirred for 16 h at room temperature. Water was added and the solution acidified with 2M hydrochloric acid and then extracted with ethyl acetate. The organic layer was dried (MgSO4) and evaporated. Trituration with diethyl ether/iso-hexane afforded the subtitle compound (1.790 g).

WORKUP

后处理

extractionextracted with ethyl acetate
dry with materialThe organic layer was dried (MgSO4)
customevaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d6b7725cc0934719852c6b00c7d12421
来源数据集: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08299246B2
来源说明: uspto-grants-2012_10

反应 SMILES

C[O:2][C:3](=[O:43])[C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[C:6]([N:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH:17][C:18]([CH3:41])([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[O:26][CH2:27][CH2:28][N:29]([CH3:40])[C:30]([O:32][CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[O:31])[CH3:19])[C:12]2=[O:42])[CH:5]=1.O.[OH-].[Li+].Cl>C1COCC1.O>[CH2:21]([O:26][CH2:27][CH3:28])[CH3:20].[CH3:7][CH2:6][CH2:5][CH:4]([CH3:9])[CH3:3].[CH3:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:43])=[O:2])=[CH:5][C:6]=1[N:11]1[CH:16]=[CH:15][N:14]=[C:13]([NH:17][C:18]([CH3:19])([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[O:26][CH2:27][CH2:28][N:29]([CH3:40])[C:30]([O:32][CH2:33][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)=[O:31])[CH3:41])[C:12]1=[O:42]