反应详情

2-Chloro-3,4-dihydro-3,3-dimethyl-4-phenylquinolin-4-ol (0.7g., 0.0025 mole) was dissolved in dry dioxan (10 ml.). Triethylamine (0.5g) followed by N-methylpiperazine (1.92g.) were added and the mixture stirred for 4 hours. The mixture was then evaporated down to a white solid residue which was recrystallised from isopropyl alcohol to give the title compound (0.60g., m.p. 268° - 269° C) [Found: C, 75.6; H, 8.1; N, 12.15% C22H27N3O requires C, 75.6; H, 7.8; N, 12.0%].

1. additionwere added
2. customThe mixture was then evaporated down to a white solid residue which
3. customwas recrystallised from isopropyl alcohol