Hydrochloric Acid → HCID 23037335, compound

HRID 2073014Notes

Reaction equation

HRID 2073014 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]([CH2:17][C:18]([NH:20][CH2:21][CH2:22][N:23]([CH3:25])[CH3:24])=[O:19])[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.[ClH:26]>C(O)(C)C>[OH2:19].[ClH:26].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]([CH2:17][C:18]([NH:20][CH2:21][CH2:22][N:23]([CH3:25])[CH3:24])=[O:19])[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14390292HCID 14390292, compound

Product 1

HCID 23037335HCID 23037335, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2-(4-Bromophenyl)-N-[2-(dimethylamino)ethyl]-3H-imidazo[4,5-b]pyridine-3-acetamide (2.25 g, 0.0056 mole) was treated with concentrated hydrochloric acid and isopropyl alcohol to give 2.4 g precipitate. Recrystallization from isopropyl alcohol gave 1.9 g (70%) of white solid, mp 160.5°-162° C.

Sources & evidence

ORD record
ord-d262b8bfa44a48f3b085195910977a2e
Source dataset
uspto-grants-1990_04
Patent number
US04914109

Reaction notes

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